Ontology highlight
ABSTRACT:
SUBMITTER: Kim TW
PROVIDER: S-EPMC5104888 | biostudies-literature | 2016 Nov
REPOSITORIES: biostudies-literature
Kim Tae Won TW Elme Anneli A Kusic Zvonko Z Park Joon Oh JO Udrea Anghel Adrian AA Kim Sun Young SY Ahn Joong Bae JB Valencia Ricardo Villalobos RV Krishnan Srinivasan S Bilic Ante A Manojlovic Nebojsa N Dong Jun J Guan Xuesong X Lofton-Day Catherine C Jung A Scott AS Vrdoljak Eduard E
British journal of cancer 20161013 10
<h4>Background</h4>We assessed the treatment effect of panitumumab plus best supportive care (BSC) vs BSC on overall survival (OS) in patients with chemorefractory wild-type KRAS exon 2 metastatic colorectal cancer (mCRC) and report the first prospective extended RAS analysis in a phase 3 trial.<h4>Methods</h4>Patients with wild-type KRAS exon 2 mCRC were randomised 1 : 1 to panitumumab (6 mg kg<sup>-1</sup> Q2W) plus BSC or BSC. On-study crossover was prohibited. RAS mutation status was determi ...[more]