Ontology highlight
ABSTRACT:
SUBMITTER: Gellert P
PROVIDER: S-EPMC5105193 | biostudies-literature | 2016 Nov
REPOSITORIES: biostudies-literature
Nature communications 20161109
Pre-surgical studies allow study of the relationship between mutations and response of oestrogen receptor-positive (ER+) breast cancer to aromatase inhibitors (AIs) but have been limited to small biopsies. Here in phase I of this study, we perform exome sequencing on baseline, surgical core-cuts and blood from 60 patients (40 AI treated, 20 controls). In poor responders (based on Ki67 change), we find significantly more somatic mutations than good responders. Subclones exclusive to baseline or s ...[more]