Ontology highlight
ABSTRACT:
SUBMITTER: Berryer MH
PROVIDER: S-EPMC5105197 | biostudies-literature | 2016 Nov
REPOSITORIES: biostudies-literature
Berryer Martin H MH Chattopadhyaya Bidisha B Xing Paul P Riebe Ilse I Bosoi Ciprian C Sanon Nathalie N Antoine-Bertrand Judith J Lévesque Maxime M Avoli Massimo M Hamdan Fadi F FF Carmant Lionel L Lamarche-Vane Nathalie N Lacaille Jean-Claude JC Michaud Jacques L JL Di Cristo Graziella G
Nature communications 20161109
Haploinsufficiency of the SYNGAP1 gene, which codes for a Ras GTPase-activating protein, impairs cognition both in humans and in mice. Decrease of Syngap1 in mice has been previously shown to cause cognitive deficits at least in part by inducing alterations in glutamatergic neurotransmission and premature maturation of excitatory connections. Whether Syngap1 plays a role in the development of cortical GABAergic connectivity and function remains unclear. Here, we show that Syngap1 haploinsufficie ...[more]