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Pharmacokinetics of Unboosted Atazanavir in Treatment-experienced HIV-infected Children, Adolescents and Young Adults.

ABSTRACT: HIV protease inhibitor use in pediatrics is challenging due to the poor palatability and/or toxicity of concomitant low-dose ritonavir. Atazanavir without ritonavir (unboosted) is not recommended for patients with prior virologic failure, a common problem for perinatally-infected adolescents. Atazanavir 400?mg once-daily provided suboptimal exposure. Higher unboosted doses or splitting the daily dose to twice-daily warrants investigation in this treatment-experienced population.

SUBMITTER: Cressey TR

PROVIDER: S-EPMC5106325 | biostudies-literature | 2016 Dec

REPOSITORIES: biostudies-literature

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Pharmacokinetics of Unboosted Atazanavir in Treatment-experienced HIV-infected Children, Adolescents and Young Adults.

Cressey Tim R TR Hazra Rohan R Wiznia Andrew A Foca Marc M Jean-Philippe Patrick P Graham Bobbie B King Jennifer R JR Britto Paula P Carey Vincent J VJ Acosta Edward P EP Yogev Ram R

The Pediatric infectious disease journal 20161201 12

HIV protease inhibitor use in pediatrics is challenging due to the poor palatability and/or toxicity of concomitant low-dose ritonavir. Atazanavir without ritonavir (unboosted) is not recommended for patients with prior virologic failure, a common problem for perinatally-infected adolescents. Atazanavir 400 mg once-daily provided suboptimal exposure. Higher unboosted doses or splitting the daily dose to twice-daily warrants investigation in this treatment-experienced population. ...[more]

PMID: 27583590

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| S-EPMC3165353 | biostudies-literature

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