Ontology highlight
ABSTRACT:
SUBMITTER: Burr SP
PROVIDER: S-EPMC5106373 | biostudies-literature | 2016 Nov
REPOSITORIES: biostudies-literature
Burr Stephen P SP Costa Ana S H AS Grice Guinevere L GL Timms Richard T RT Lobb Ian T IT Freisinger Peter P Dodd Roger B RB Dougan Gordon G Lehner Paul J PJ Frezza Christian C Nathan James A JA
Cell metabolism 20161027 5
Hypoxia-inducible transcription factors (HIFs) control adaptation to low oxygen environments by activating genes involved in metabolism, angiogenesis, and redox homeostasis. The finding that HIFs are also regulated by small molecule metabolites highlights the need to understand the complexity of their cellular regulation. Here we use a forward genetic screen in near-haploid human cells to identify genes that stabilize HIFs under aerobic conditions. We identify two mitochondrial genes, oxoglutara ...[more]