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The evolving world of pseudoenzymes: proteins, prejudice and zombies.


ABSTRACT: Pseudoenzymes are catalytically deficient variants of enzymes that are represented in all major enzyme families. Their regulatory functions in signalling pathways are shedding new light on the non-catalytic functions of active enzymes, and are suggesting new ways to target cellular signalling mechanisms with drugs.

SUBMITTER: Eyers PA 

PROVIDER: S-EPMC5106787 | biostudies-literature | 2016 Nov

REPOSITORIES: biostudies-literature

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The evolving world of pseudoenzymes: proteins, prejudice and zombies.

Eyers Patrick A PA   Murphy James M JM  

BMC biology 20161111 1


Pseudoenzymes are catalytically deficient variants of enzymes that are represented in all major enzyme families. Their regulatory functions in signalling pathways are shedding new light on the non-catalytic functions of active enzymes, and are suggesting new ways to target cellular signalling mechanisms with drugs. ...[more]

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