Ontology highlight
ABSTRACT:
SUBMITTER: Shi M
PROVIDER: S-EPMC5107127 | biostudies-literature | 2016 Nov
REPOSITORIES: biostudies-literature
Alzheimer's & dementia : the journal of the Alzheimer's Association 20160524 11
<h4>Introduction</h4>Alzheimer's disease (AD) and Parkinson's disease (PD) involve tau pathology. Tau is detectable in blood, but its clearance from neuronal cells and the brain is poorly understood.<h4>Methods</h4>Tau efflux from the brain to the blood was evaluated by administering radioactively labeled and unlabeled tau intracerebroventricularly in wild-type and tau knock-out mice, respectively. Central nervous system (CNS)-derived tau in L1CAM-containing exosomes was further characterized ex ...[more]