Dataset Information
CNS tau efflux via exosomes is likely increased in Parkinson's disease but not in Alzheimer's disease.
Ontology highlight
ABSTRACT: Introduction
Alzheimer's disease (AD) and Parkinson's disease (PD) involve tau pathology. Tau is detectable in blood, but its clearance from neuronal cells and the brain is poorly understood.Methods
Tau efflux from the brain to the blood was evaluated by administering radioactively labeled and unlabeled tau intracerebroventricularly in wild-type and tau knock-out mice, respectively. Central nervous system (CNS)-derived tau in L1CAM-containing exosomes was further characterized extensively in human plasma, including by single molecule array technology with 303 subjects.Results
The efflux of Tau, including a fraction via CNS-derived L1CAM exosomes, was observed in mice. In human plasma, tau was explicitly identified within L1CAM exosomes. In contrast to AD patients, L1CAM exosomal tau was significantly higher in PD patients than controls and correlated with cerebrospinal fluid tau.Conclusions
Tau is readily transported from the brain to the blood. The mechanisms of CNS tau efflux are likely different between AD and PD.
SUBMITTER: Shi M
PROVIDER: S-EPMC5107127 | biostudies-literature | 2016 Nov
REPOSITORIES: biostudies-literature
Publications
CNS tau efflux via exosomes is likely increased in Parkinson's disease but not in Alzheimer's disease.
Alzheimer's & dementia : the journal of the Alzheimer's Association 20160524 11
<h4>Introduction</h4>Alzheimer's disease (AD) and Parkinson's disease (PD) involve tau pathology. Tau is detectable in blood, but its clearance from neuronal cells and the brain is poorly understood.<h4>Methods</h4>Tau efflux from the brain to the blood was evaluated by administering radioactively labeled and unlabeled tau intracerebroventricularly in wild-type and tau knock-out mice, respectively. Central nervous system (CNS)-derived tau in L1CAM-containing exosomes was further characterized ex ...[more]