Ontology highlight
ABSTRACT:
SUBMITTER: Pan D
PROVIDER: S-EPMC5107210 | biostudies-literature | 2016 Dec
REPOSITORIES: biostudies-literature
Pan Deng D Roy Somdutta S Gascard Philippe P Zhao Jianxin J Chen-Tanyolac Chira C Tlsty Thea D TD
Cellular signalling 20161002 12
Endogenous Plastic Somatic (ePS) cells isolated from adult human tissues exhibit extensive lineage plasticity in vitro and in vivo. Here we visualize these rare ePS cells in a latent state, i.e. lacking SOX2, OCT3/4 and NANOG (SON) expression, in non-diseased breast specimens through immunohistochemical analysis of previously identified ePS-specific biomarkers (CD73<sup>+</sup>, EpCAM<sup>+</sup> and CD90<sup>-</sup>). We also report a novel mechanism by which these latent ePS cells acquire SON ...[more]