Ontology highlight
ABSTRACT:
SUBMITTER: Thompson P
PROVIDER: S-EPMC5108038 | biostudies-literature | 2016 Nov
REPOSITORIES: biostudies-literature
ACS medicinal chemistry letters 20160920 11
Antibody-drug conjugates (ADCs) have become a powerful platform to deliver cytotoxic agents selectively to cancer cells. ADCs have traditionally been prepared by stochastic conjugation of a cytotoxic drug using an antibody's native cysteine or lysine residues. Through strategic selection of the mammalian expression host, we were able to introduce azide-functionalized glycans onto a homogeneously glycosylated anti-EphA2 monoclonal antibody in one step. Conjugation with an alkyne-bearing pyrrolobe ...[more]