Ontology highlight
ABSTRACT:
SUBMITTER: Csomos K
PROVIDER: S-EPMC5108309 | biostudies-literature | 2016 Aug
REPOSITORIES: biostudies-literature
Csomós Krisztián K Kristóf Endre E Jakob Bernadett B Csomós István I Kovács György G Rotem Omri O Hodrea Judit J Bagoly Zsuzsa Z Muszbek Laszlo L Balajthy Zoltán Z Csősz Éva É Fésüs László L
Cell death & disease 20160811 8
Neutrophil extracellular trap (NET) ejected from activated dying neutrophils is a highly ordered structure of DNA and selected proteins capable to eliminate pathogenic microorganisms. Biochemical determinants of the non-randomly formed stable NETs have not been revealed so far. Studying the formation of human NETs we have observed that polyamines were incorporated into the NET. Inhibition of myeloperoxidase, which is essential for NET formation and can generate reactive chlorinated polyamines th ...[more]