Ontology highlight
ABSTRACT:
SUBMITTER: Lampropoulou V
PROVIDER: S-EPMC5108454 | biostudies-literature | 2016 Jul
REPOSITORIES: biostudies-literature
Lampropoulou Vicky V Sergushichev Alexey A Bambouskova Monika M Nair Sharmila S Vincent Emma E EE Loginicheva Ekaterina E Cervantes-Barragan Luisa L Ma Xiucui X Huang Stanley Ching-Cheng SC Griss Takla T Weinheimer Carla J CJ Khader Shabaana S Randolph Gwendalyn J GJ Pearce Edward J EJ Jones Russell G RG Diwan Abhinav A Diamond Michael S MS Artyomov Maxim N MN
Cell metabolism 20160630 1
Remodeling of the tricarboxylic acid (TCA) cycle is a metabolic adaptation accompanying inflammatory macrophage activation. During this process, endogenous metabolites can adopt regulatory roles that govern specific aspects of inflammatory response, as recently shown for succinate, which regulates the pro-inflammatory IL-1β-HIF-1α axis. Itaconate is one of the most highly induced metabolites in activated macrophages, yet its functional significance remains unknown. Here, we show that itaconate m ...[more]