Ontology highlight
ABSTRACT:
SUBMITTER: Lin WW
PROVIDER: S-EPMC5108530 | biostudies-literature | 2016 Nov
REPOSITORIES: biostudies-literature
Lin Wen-Hsuan W WW Nish Simone A SA Yen Bonnie B Chen Yen-Hua YH Adams William C WC Kratchmarov Radomir R Rothman Nyanza J NJ Bhandoola Avinash A Xue Hai-Hui HH Reiner Steven L SL
Cell reports 20161101 7
Selected CD8<sup>+</sup> T cells must divide, produce differentiated effector cells, and self-renew, often repeatedly. We now show that silencing expression of the transcription factor TCF1 marks loss of self-renewal by determined effector cells and that this requires cell division. In acute infections, the first three CD8<sup>+</sup> T cell divisions produce daughter cells with unequal proliferative signaling but uniform maintenance of TCF1 expression. The more quiescent initial daughter cells ...[more]