Ontology highlight
ABSTRACT:
SUBMITTER: Kim SE
PROVIDER: S-EPMC5108575 | biostudies-literature | 2016 Nov
REPOSITORIES: biostudies-literature
Kim Sung Eun SE Zhang Li L Ma Kai K Riegman Michelle M Chen Feng F Ingold Irina I Conrad Marcus M Turker Melik Ziya MZ Gao Minghui M Jiang Xuejun X Monette Sebastien S Pauliah Mohan M Gonen Mithat M Zanzonico Pat P Quinn Thomas T Wiesner Ulrich U Bradbury Michelle S MS Overholtzer Michael M
Nature nanotechnology 20160926 11
The design of cancer-targeting particles with precisely tuned physicochemical properties may enhance the delivery of therapeutics and access to pharmacological targets. However, a molecular-level understanding of the interactions driving the fate of nanomedicine in biological systems remains elusive. Here, we show that ultrasmall (<10 nm in diameter) poly(ethylene glycol)-coated silica nanoparticles, functionalized with melanoma-targeting peptides, can induce a form of programmed cell death know ...[more]