Ontology highlight
ABSTRACT:
SUBMITTER: Lin CS
PROVIDER: S-EPMC5109203 | biostudies-literature | 2016 Nov
REPOSITORIES: biostudies-literature
Lin Chuan-Sheng CS Tsai Yu-Huan YH Chang Chih-Jung CJ Tseng Shun-Fu SF Wu Tsung-Ru TR Lu Chia-Chen CC Wu Ting-Shu TS Lu Jang-Jih JJ Horng Jim-Tong JT Martel Jan J Ojcius David M DM Lai Hsin-Chih HC Young John D JD
Scientific reports 20161115
Iron availability affects swarming and biofilm formation in various bacterial species. However, how bacteria sense iron and coordinate swarming and biofilm formation remains unclear. Using Serratia marcescens as a model organism, we identify here a stage-specific iron-regulatory machinery comprising a two-component system (TCS) and the TCS-regulated iron chelator 2-isocyano-6,7-dihydroxycoumarin (ICDH-Coumarin) that directly senses and modulates environmental ferric iron (Fe<sup>3+</sup>) availa ...[more]