Ontology highlight
ABSTRACT:
SUBMITTER: Wang R
PROVIDER: S-EPMC5109228 | biostudies-literature | 2016 Nov
REPOSITORIES: biostudies-literature
Wang Rong R Zhang Yanjin Y Xu Liran L Lin Yan Y Yang Xiaofeng X Bai Liang L Chen Yulong Y Zhao Sihai S Fan Jianglin J Cheng Xianwu X Liu Enqi E
Scientific reports 20161115
Atherosclerosis is a serious public health concern. Excessive inflammatory responses of vascular cells are considered a pivotal pathogenesis mechanism underlying atherosclerosis development. It is known that Janus kinase/signal transducer and activator of transcription 3 (JAK/STAT3) signalling plays an important role in atherosclerosis progression. Protein inhibitor of activated STAT3 (PIAS3) is the key negative regulator of JAK/STAT3 signalling. However, its effect on atherogenesis is unknown. ...[more]