Ontology highlight
ABSTRACT:
SUBMITTER: Falchook GS
PROVIDER: S-EPMC5109769 | biostudies-literature | 2016
REPOSITORIES: biostudies-literature
Falchook Gerald S GS Leidner Rom R Stankevich Elizabeth E Piening Brian B Bifulco Carlo C Lowy Israel I Fury Matthew G MG
Journal for immunotherapy of cancer 20161115
<h4>Background</h4>Basal cell carcinoma (BCC) and cutaneous squamous cell carcinoma (CSCC) share exposure to UV light as the dominant risk factor, and these tumors therefore harbor high mutation burdens. In other malignancies, high mutation burden has been associated with clinical benefit from therapy with antibodies directed against the Programmed Death 1 (PD-1) immune checkpoint receptor. Highly mutated tumors are more likely to express immunogenic tumor neoantigens that attract effector T cel ...[more]