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Renal and Cardiovascular Morbidities Associated with APOL1 Status among African-American and Non-African-American Children with Focal Segmental Glomerulosclerosis.


ABSTRACT: BACKGROUND AND OBJECTIVES:African-American (AA) children with focal segmental glomerulosclerosis (FSGS) have later onset disease that progresses more rapidly than in non-AA children. It is unclear how APOL1 genotypes contribute to kidney disease risk, progression, and cardiovascular morbidity in children. DESIGN SETTING PARTICIPANTS AND MEASUREMENTS:We examined the prevalence of APOL1 genotypes and associated cardiovascular phenotypes among children with FSGS in the Chronic Kidney Disease in Children (CKiD) study; an ongoing multicenter prospective cohort study of children aged 1-16?years with mild to moderate kidney disease. RESULTS:A total of 140 AA children in the CKiD study were genotyped. High risk (HR) APOL1 genotypes were present in 24% of AA children (33/140) and were associated with FSGS, p??3?mg/l (33 vs. 15%, p?=?0.12), and obesity (48 vs. 19%, p?=?0.01). There were no differences in glomerular filtration rate, hemoglobin, iPTH, or calcium-phosphate product. CONCLUSION:AA children with HR APOL1 genotype and FSGS have increase prevalence of obesity and LVH despite a later age of FSGS onset, while adjusting for socioeconomic status. Treatment of obesity may be an important component of chronic kidney disease and LVH management in this population.

SUBMITTER: Woroniecki RP 

PROVIDER: S-EPMC5110572 | biostudies-literature | 2016

REPOSITORIES: biostudies-literature

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Renal and Cardiovascular Morbidities Associated with <i>APOL1</i> Status among African-American and Non-African-American Children with Focal Segmental Glomerulosclerosis.

Woroniecki Robert P RP   Ng Derek K DK   Limou Sophie S   Winkler Cheryl A CA   Reidy Kimberly J KJ   Mitsnefes Mark M   Sampson Matthew G MG   Wong Craig S CS   Warady Bradley A BA   Furth Susan L SL   Kopp Jeffrey B JB   Kaskel Frederick J FJ  

Frontiers in pediatrics 20161117


<h4>Background and objectives</h4>African-American (AA) children with focal segmental glomerulosclerosis (FSGS) have later onset disease that progresses more rapidly than in non-AA children. It is unclear how <i>APOL1</i> genotypes contribute to kidney disease risk, progression, and cardiovascular morbidity in children.<h4>Design setting participants and measurements</h4>We examined the prevalence of <i>APOL1</i> genotypes and associated cardiovascular phenotypes among children with FSGS in the  ...[more]

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