Ontology highlight
ABSTRACT:
SUBMITTER: Pan G
PROVIDER: S-EPMC5110883 | biostudies-literature | 2016
REPOSITORIES: biostudies-literature
Pan Guodong G Deshpande Mandar M Thandavarayan Rajarajan A RA Palaniyandi Suresh Selvaraj SS
Journal of diabetes research 20161102
Aldehyde dehydrogenase (ALDH) gene superfamily consists of 19 isozymes. They are present in various organs and involved in metabolizing aldehydes that are biologically generated. For instance, ALDH2, a cardiac mitochondrial ALDH isozyme, is known to detoxify 4-hydroxy-2-nonenal, a reactive aldehyde produced upon lipid peroxidation in diabetic conditions. We hypothesized that inhibition of ALDH leads to the accumulation of unmetabolized 4HNE and consequently exacerbates injury in cells subjected ...[more]