Ontology highlight
ABSTRACT:
SUBMITTER: Too IH
PROVIDER: S-EPMC5111112 | biostudies-literature | 2016 Nov
REPOSITORIES: biostudies-literature
Too Issac Horng Khit IH Yeo Huimin H Sessions October Michael OM Yan Benedict B Libau Eshele Anak EA Howe Josephine L C JL Lim Ze Qin ZQ Suku-Maran Shalini S Ong Wei-Yi WY Chua Kaw Bing KB Wong Boon Seng BS Chow Vincent T K VT Alonso Sylvie S
Scientific reports 20161116
Enterovirus 71 (EV71) causing Hand, Foot and Mouth Disease, is regarded as the most important neurotropic virus worldwide. EV71 is believed to replicate in muscles and infect motor neurons to reach the central nervous system (CNS). To further investigate the mechanisms involved, we have employed the motor neuron cell line NSC-34. NSC-34 cells were permissive to EV71 and virus production yields were strain-dependent with differential efficacy at the entry, replication and egress steps. Furthermor ...[more]