Simultaneous assessment of the synthesis rate and transcapillary escape rate of albumin in inflammation and surgery.

ABSTRACT:

Background

Better knowledge of albumin kinetics is needed to define the indications for albumin use in clinical practice. This study involved two approaches: the synthesis rate and transcapillary escape rate of albumin were measured simultaneously at different levels of plasma albumin concentration in relation to acute inflammation and surgery; and two different tracers were compared to determine plasma volume and the transcapillary escape rate.

Methods

Healthy volunteers (n = 10), patients with acute inflammatory abdominal disease (n = 10), and patients undergoing elective pancreatic resection (n = 10) were studied. The albumin synthesis rate was measured by the incorporation of deuterium-labeled phenylalanine. Plasma volume and the transcapillary escape rate were assessed

SUBMITTER: Komaromi A 

PROVIDER: S-EPMC5111293 | biostudies-literature | 2016 Nov

REPOSITORIES: biostudies-literature