Ontology highlight
ABSTRACT:
SUBMITTER: Zaia J
PROVIDER: S-EPMC5111364 | biostudies-literature | 2016 Nov
REPOSITORIES: biostudies-literature
Zaia Joseph J Khatri Kshitij K Klein Joshua J Shao Chun C Sheng Yuewei Y Viner Rosa R
Analytical chemistry 20161017 21
Low-molecular weight heparins (LMWH) prepared by partial depolymerization of unfractionated heparin are used globally to treat coagulation disorders on an outpatient basis. Patent protection for several LMWH has expired and abbreviated new drug applications have been approved by the Food and Drug Administration. As a result, reverse engineering of LMWH for biosimilar LMWH has become an active global endeavor. Traditionally, the molecular weight distributions of LMWH preparations have been determ ...[more]