Ontology highlight
ABSTRACT:
SUBMITTER: Paap RH
PROVIDER: S-EPMC5111667 | biostudies-literature | 2016 Nov
REPOSITORIES: biostudies-literature
Proceedings of the National Academy of Sciences of the United States of America 20161024 45
The forkhead transcription factor FoxO6 is prominently expressed during development of the murine neocortex. However, its function in cortical development is as yet unknown. We now demonstrate that cortical development is altered in <i>FoxO6</i><sup>+/-</sup> and <i>FoxO6</i><sup><i>-/-</i></sup> mice, showing migrating neurons halted in the intermediate zone. Using a <i>FoxO6</i>-directed siRNA approach, we substantiate the requirement of FoxO6 for a correct radial migration in the developing n ...[more]