Dataset Information

Progressive brain changes in patients with chronic fatigue syndrome: A longitudinal MRI study.

ABSTRACT:

Purpose

To examine progressive brain changes associated with chronic fatigue syndrome (CFS).

Materials and methods

We investigated progressive brain changes with longitudinal MRI in 15 CFS and 10 normal controls (NCs) scanned twice 6 years apart on the same 1.5 Tesla (T) scanner. MR images yielded gray matter (GM) volumes, white matter (WM) volumes, and T1- and T2-weighted signal intensities (T1w and T2w). Each participant was characterized with Bell disability scores, and somatic and neurological symptom scores. We tested for differences in longitudinal changes between CFS and NC groups, inter group differences between pooled CFS and pooled NC populations, and correlations between MRI and symptom scores using voxel based morphometry. The analysis methodologies were first optimized using simulated atrophy.

Results

We found a significant decrease in WM volumes in the left inferior fronto-occipital fasciculus (IFOF) in CFS while in NCs it was unchanged (family wise error adjusted cluster level P value, P_FWE < 0.05). This longitudinal finding was consolidated by the group comparisons which detected significantly decreased regional WM volumes in adjacent regions (P_FWE < 0.05) and decreased GM and blood volumes in contralateral regions (P_FWE < 0.05). Moreover, the regional GM and WM volumes and T2w in those areas showed significant correlations with CFS symptom scores (P_FWE < 0.05).

Conclusion

The results suggested that CFS is associated with IFOF WM deficits which continue to deteriorate at an abnormal rate. J. Magn. Reson. Imaging 2016;44:1301-1311.

SUBMITTER: Shan ZY

PROVIDER: S-EPMC5111735 | biostudies-literature | 2016 Nov

REPOSITORIES: biostudies-literature

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Publications

Progressive brain changes in patients with chronic fatigue syndrome: A longitudinal MRI study.

Shan Zack Y ZY Kwiatek Richard R Burnet Richard R Del Fante Peter P Staines Donald R DR Marshall-Gradisnik Sonya M SM Barnden Leighton R LR

Journal of magnetic resonance imaging : JMRI 20160428 5

<h4>Purpose</h4>To examine progressive brain changes associated with chronic fatigue syndrome (CFS).<h4>Materials and methods</h4>We investigated progressive brain changes with longitudinal MRI in 15 CFS and 10 normal controls (NCs) scanned twice 6 years apart on the same 1.5 Tesla (T) scanner. MR images yielded gray matter (GM) volumes, white matter (WM) volumes, and T1- and T2-weighted signal intensities (T1w and T2w). Each participant was characterized with Bell disability scores, and somatic ...[more]

PMID: 27123773

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Project description:The mechanism underlying neurological dysfunction in chronic fatigue syndrome/myalgic encephalomyelitis (CFS/ME) is yet to be established. This study investigated the temporal complexity of blood oxygenation level dependent (BOLD) changes in response to the Stroop task in CFS patients. 43 CFS patients (47.4?±?11.8?yrs) and 26 normal controls (NCs, 43.4?±?13.9?yrs) were included in this study. Their mental component summary (MCS) and physical component summary (PCS) from the 36-item Short Form Health Survey (SF-36) questionnaire were recorded. Their Stroop colour-word task performance was measured by accuracy and response time (RT). The BOLD changes associated with the Stroop task were evaluated using a 2-level general linear model approach. The temporal complexity of the BOLD responses, a measure of information capacity and thus adaptability to a challenging environment, in each activated region was measured by sample entropy (SampEn). The CFS patients showed significantly longer RTs than the NCs (P?<?0.05) but no significant difference in accuracy. One sample t-tests for the two groups (Family wise error adjusted PFWE?<?0.05) showed more BOLD activation regions in the CFS, although a two sample group comparison did not show significant difference. BOLD SampEns in ten regions were significantly lower (FDR-q?<?0.05) in CFS patients. BOLD SampEns in 15 regions were significantly associated with PCS (FDR-q?<?0.05) and in 9 regions were associated with MCS (FDR-q?<?0.05) across all subjects. SampEn of the BOLD signal in the medioventral occipital cortex could explain 40% and 31% of the variance in the SF-36 PCS and MCS scores, and those in the precentral gyrus could explain an additional 16% and 7% across all subjects. This is the first study to investigate BOLD signal SampEn in response to tasks in CFS. The results suggest the brain responds differently to a cognitive challenge in patients with CFS, with recruitment of wider regions to compensate for lower information capacity.

Dataset Information

Progressive brain changes in patients with chronic fatigue syndrome: A longitudinal MRI study.

Purpose

Materials and methods

Results

Conclusion

Publications

Progressive brain changes in patients with chronic fatigue syndrome: A longitudinal MRI study.

Similar Datasets

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