Ontology highlight
ABSTRACT:
SUBMITTER: Collins KH
PROVIDER: S-EPMC5112513 | biostudies-literature | 2016 Nov
REPOSITORIES: biostudies-literature
Collins Kelsey H KH Paul Heather A HA Hart David A DA Reimer Raylene A RA Smith Ian C IC Rios Jaqueline L JL Seerattan Ruth A RA Herzog Walter W
Scientific reports 20161117
The chronic low-level inflammation associated with obesity is known to deleteriously affect muscle composition. However, the manner in which obesity leads to muscle loss has not been explored in detail or in an integrated manner following a short-term metabolic challenge. In this paper, we evaluated the relationships between compromised muscle integrity, diet, systemic inflammatory mediators, adipose tissue, and gut microbiota in male Sprague-Dawley rats. We show that intramuscular fat, fibrosis ...[more]