Ontology highlight
ABSTRACT:
SUBMITTER: Lambricht L
PROVIDER: S-EPMC5113100 | biostudies-literature | 2016 Sep
REPOSITORIES: biostudies-literature
Lambricht Laure L Vanvarenberg Kevin K De Beuckelaer Ans A Van Hoecke Lien L Grooten Johan J Ucakar Bernard B Lipnik Pascale P Sanders Niek N NN Lienenklaus Stefan S Préat Véronique V Vandermeulen Gaëlle G
Molecular therapy : the journal of the American Society of Gene Therapy 20160620 9
DNA vaccination holds great promise for the prevention and treatment of cancer and infectious diseases. However, the clinical ability of DNA vaccines is still controversial due to the limited immune response initially observed in humans. We hypothesized that electroporation of a plasmid encoding the HIV-1 Gag viral capsid protein would enhance cancer DNA vaccine potency. DNA electroporation used to deliver plasmids in vivo, induced type I interferons, thereby supporting the activation of innate ...[more]