Ontology highlight
ABSTRACT:
SUBMITTER: Peeva L
PROVIDER: S-EPMC5113664 | biostudies-literature | 2016 Oct
REPOSITORIES: biostudies-literature
Peeva Ludmila L Da Silva Burgal Joao J Heckenast Zsofia Z Brazy Florine F Cazenave Florian F Livingston Andrew A
Angewandte Chemie (International ed. in English) 20160927 43
Pharmaceutical production typically involves multiple reaction steps with separations between successive reactions. Two processes which complicate the transition from batch to continuous operation in multistep synthesis are solvent exchange (especially high-boiling- to low-boiling-point solvent), and catalyst separation. Demonstrated here is membrane separation as an enabling platform for undertaking these processes during continuous operation. Two consecutive reactions are performed in differen ...[more]