Ontology highlight
ABSTRACT:
SUBMITTER: Crisman TJ
PROVIDER: S-EPMC5113897 | biostudies-literature | 2016
REPOSITORIES: biostudies-literature
Crisman Thomas J TJ Zelaya Ivette I Laks Dan R DR Zhao Yining Y Kawaguchi Riki R Gao Fuying F Kornblum Harley I HI Coppola Giovanni G
PloS one 20161117 11
We present here a novel genetic algorithm-based random forest (GARF) modeling technique that enables a reduction in the complexity of large gene disease signatures to highly accurate, greatly simplified gene panels. When applied to 803 glioblastoma multiforme samples, this method allowed the 840-gene Verhaak et al. gene panel (the standard in the field) to be reduced to a 48-gene classifier, while retaining 90.91% classification accuracy, and outperforming the best available alternative methods. ...[more]