Ontology highlight
ABSTRACT:
SUBMITTER: Lee WY
PROVIDER: S-EPMC5114121 | biostudies-literature | 2010 Apr
REPOSITORIES: biostudies-literature
Lee Woo-Yong WY Moriarty Tara J TJ Wong Connie H Y CH Zhou Hong H Strieter Robert M RM van Rooijen Nico N Chaconas George G Kubes Paul P
Nature immunology 20100314 4
Here we investigate the dynamics of the hepatic intravascular immune response to a pathogen relevant to invariant natural killer T cells (iNKT cells). Immobilized Kupffer cells with highly ramified extended processes into multiple sinusoids could effectively capture blood-borne, disseminating Borrelia burgdorferi, creating a highly efficient surveillance and filtering system. After ingesting B. burgdorferi, Kupffer cells induced chemokine receptor CXCR3-dependent clustering of iNKT cells. Kupffe ...[more]