Ontology highlight
ABSTRACT:
SUBMITTER: Kebir H
PROVIDER: S-EPMC5114125 | biostudies-literature | 2007 Oct
REPOSITORIES: biostudies-literature
Kebir Hania H Kreymborg Katharina K Ifergan Igal I Dodelet-Devillers Aurore A Cayrol Romain R Bernard Monique M Giuliani Fabrizio F Arbour Nathalie N Becher Burkhard B Prat Alexandre A
Nature medicine 20070909 10
T(H)17 lymphocytes appear to be essential in the pathogenesis of numerous inflammatory diseases. We demonstrate here the expression of IL-17 and IL-22 receptors on blood-brain barrier endothelial cells (BBB-ECs) in multiple sclerosis lesions, and show that IL-17 and IL-22 disrupt BBB tight junctions in vitro and in vivo. Furthermore, T(H)17 lymphocytes transmigrate efficiently across BBB-ECs, highly express granzyme B, kill human neurons and promote central nervous system inflammation through CD ...[more]