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Human TH17 lymphocytes promote blood-brain barrier disruption and central nervous system inflammation.


ABSTRACT: T(H)17 lymphocytes appear to be essential in the pathogenesis of numerous inflammatory diseases. We demonstrate here the expression of IL-17 and IL-22 receptors on blood-brain barrier endothelial cells (BBB-ECs) in multiple sclerosis lesions, and show that IL-17 and IL-22 disrupt BBB tight junctions in vitro and in vivo. Furthermore, T(H)17 lymphocytes transmigrate efficiently across BBB-ECs, highly express granzyme B, kill human neurons and promote central nervous system inflammation through CD4+ lymphocyte recruitment.

SUBMITTER: Kebir H 

PROVIDER: S-EPMC5114125 | biostudies-literature | 2007 Oct

REPOSITORIES: biostudies-literature

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Human TH17 lymphocytes promote blood-brain barrier disruption and central nervous system inflammation.

Kebir Hania H   Kreymborg Katharina K   Ifergan Igal I   Dodelet-Devillers Aurore A   Cayrol Romain R   Bernard Monique M   Giuliani Fabrizio F   Arbour Nathalie N   Becher Burkhard B   Prat Alexandre A  

Nature medicine 20070909 10


T(H)17 lymphocytes appear to be essential in the pathogenesis of numerous inflammatory diseases. We demonstrate here the expression of IL-17 and IL-22 receptors on blood-brain barrier endothelial cells (BBB-ECs) in multiple sclerosis lesions, and show that IL-17 and IL-22 disrupt BBB tight junctions in vitro and in vivo. Furthermore, T(H)17 lymphocytes transmigrate efficiently across BBB-ECs, highly express granzyme B, kill human neurons and promote central nervous system inflammation through CD  ...[more]

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