Ontology highlight
ABSTRACT:
SUBMITTER: Mokalled MH
PROVIDER: S-EPMC5114142 | biostudies-literature | 2016 Nov
REPOSITORIES: biostudies-literature
Science (New York, N.Y.) 20161101 6312
Unlike mammals, zebrafish efficiently regenerate functional nervous system tissue after major spinal cord injury. Whereas glial scarring presents a roadblock for mammalian spinal cord repair, glial cells in zebrafish form a bridge across severed spinal cord tissue and facilitate regeneration. We performed a genome-wide profiling screen for secreted factors that are up-regulated during zebrafish spinal cord regeneration. We found that connective tissue growth factor a (ctgfa) is induced in and ar ...[more]