Ontology highlight
ABSTRACT:
SUBMITTER: Dan A
PROVIDER: S-EPMC5114158 | biostudies-literature | 2016 Dec
REPOSITORIES: biostudies-literature
Dan Arkaprava A Huang Ryan B RB Leckband Deborah E DE
Annals of biomedical engineering 20160617 12
We describe an equibiaxial cell stretcher and hybrid, elastic membrane platform designed for dynamic imaging of cells on substrates with physiological stiffness undergoing cyclic stretch. Studies enabled by this device revealed that both substrate stiffness and cyclic stretch coordinately protect pulmonary endothelial monolayers against thrombin-induced disruption. The fluorescence imaging possible with the designed hybrid membranes further revealed similarities and differences in actin and cell ...[more]