Ontology highlight
ABSTRACT:
SUBMITTER: Sacco F
PROVIDER: S-EPMC5114537 | biostudies-literature | 2016 Nov
REPOSITORIES: biostudies-literature
Sacco Francesca F Humphrey Sean J SJ Cox Jürgen J Mischnik Marcel M Schulte Anke A Klabunde Thomas T Schäfer Matthias M Mann Matthias M
Nature communications 20161114
Insulin-secreting beta cells play an essential role in maintaining physiological blood glucose levels, and their dysfunction leads to the development of diabetes. To elucidate the signalling events regulating insulin secretion, we applied a recently developed phosphoproteomics workflow. We quantified the time-resolved phosphoproteome of murine pancreatic cells following their exposure to glucose and in combination with small molecule compounds that promote insulin secretion. The quantitative pho ...[more]