Survival Benefits of Statins for Primary Prevention: A Cohort Study.

ABSTRACT:

Objectives

Estimate the effect of statin prescription on mortality in the population of England and Wales with no previous history of cardiovascular disease.

Methods

Primary care records from The Health Improvement Network 1987-2011 were used. Four cohorts of participants aged 60, 65, 70, or 75 years at baseline included 118,700, 199,574, 247,149, and 194,085 participants; and 1.4, 1.9, 1.8, and 1.1 million person-years of data, respectively. The exposure was any statin prescription at any time before the participant reached the baseline age (60, 65, 70 or 75) and the outcome was all-cause mortality at any age above the baseline age. The hazard of mortality associated with statin prescription was calculated by Cox's proportional hazard regressions, adjusted for sex, year of

SUBMITTER: Gitsels LA 

PROVIDER: S-EPMC5115824 | biostudies-literature | 2016

REPOSITORIES: biostudies-literature