Multidimensional heritability analysis of neuroanatomical shape.
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ABSTRACT:
SUBMITTER: Ge T
PROVIDER: S-EPMC5116071 | biostudies-literature | 2016 Nov
REPOSITORIES: biostudies-literature
Publications
Multidimensional heritability analysis of neuroanatomical shape.
Ge Tian T Reuter Martin M Winkler Anderson M AM Holmes Avram J AJ Lee Phil H PH Tirrell Lee S LS Roffman Joshua L JL Buckner Randy L RL Smoller Jordan W JW Sabuncu Mert R MR
Nature communications 20161115
In the dawning era of large-scale biomedical data, multidimensional phenotype vectors will play an increasing role in examining the genetic underpinnings of brain features, behaviour and disease. For example, shape measurements derived from brain MRI scans are multidimensional geometric descriptions of brain structure and provide an alternate class of phenotypes that remains largely unexplored in genetic studies. Here we extend the concept of heritability to multidimensional traits, and present ...[more]
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