Dataset Information

Subcortical volumetric abnormalities in bipolar disorder.

ABSTRACT: Considerable uncertainty exists about the defining brain changes associated with bipolar disorder (BD). Understanding and quantifying the sources of uncertainty can help generate novel clinical hypotheses about etiology and assist in the development of biomarkers for indexing disease progression and prognosis. Here we were interested in quantifying case-control differences in intracranial volume (ICV) and each of eight subcortical brain measures: nucleus accumbens, amygdala, caudate, hippocampus, globus pallidus, putamen, thalamus, lateral ventricles. In a large study of 1710 BD patients and 2594 healthy controls, we found consistent volumetric reductions in BD patients for mean hippocampus (Cohen's d=-0.232; P=3.50 × 10^-7) and thalamus (d=-0.148; P=4.27 × 10^-3) and enlarged lateral ventricles (d=-0.260; P=3.93 × 10^-5) in patients. No significant effect of age at illness onset was detected. Stratifying patients based on clinical subtype (BD type I or type II) revealed that BDI patients had significantly larger lateral ventricles and smaller hippocampus and amygdala than controls. However, when comparing BDI and BDII patients directly, we did not detect any significant differences in brain volume. This likely represents similar etiology between BD subtype classifications. Exploratory analyses revealed significantly larger thalamic volumes in patients taking lithium compared with patients not taking lithium. We detected no significant differences between BDII patients and controls in the largest such comparison to date. Findings in this study should be interpreted with caution and with careful consideration of the limitations inherent to meta-analyzed neuroimaging comparisons.

SUBMITTER: Hibar DP

PROVIDER: S-EPMC5116479 | biostudies-literature | 2016 Dec

REPOSITORIES: biostudies-literature

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Subcortical volumetric abnormalities in bipolar disorder.

Hibar D P DP Westlye L T LT van Erp T G M TG Rasmussen J J Leonardo C D CD Faskowitz J J Haukvik U K UK Hartberg C B CB Doan N T NT Agartz I I Dale A M AM Gruber O O Krämer B B Trost S S Liberg B B Abé C C Ekman C J CJ Ingvar M M Landén M M Fears S C SC Freimer N B NB Bearden C E CE Sprooten E E Glahn D C DC Pearlson G D GD Emsell L L Kenney J J Scanlon C C McDonald C C Cannon D M DM Almeida J J Versace A A Caseras X X Lawrence N S NS Phillips M L ML Dima D D Delvecchio G G Frangou S S Satterthwaite T D TD Wolf D D Houenou J J Henry C C Malt U F UF Bøen E E Elvsåshagen T T Young A H AH Lloyd A J AJ Goodwin G M GM Mackay C E CE Bourne C C Bilderbeck A A Abramovic L L Boks M P MP van Haren N E M NE Ophoff R A RA Kahn R S RS Bauer M M Pfennig A A Alda M M Hajek T T Mwangi B B Soares J C JC Nickson T T Dimitrova R R Sussmann J E JE Hagenaars S S Whalley H C HC McIntosh A M AM Thompson P M PM Andreassen O A OA

Molecular psychiatry 20160209 12

Considerable uncertainty exists about the defining brain changes associated with bipolar disorder (BD). Understanding and quantifying the sources of uncertainty can help generate novel clinical hypotheses about etiology and assist in the development of biomarkers for indexing disease progression and prognosis. Here we were interested in quantifying case-control differences in intracranial volume (ICV) and each of eight subcortical brain measures: nucleus accumbens, amygdala, caudate, hippocampus ...[more]

PMID: 26857596

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Project description:Background: Cognitive frailty (CF) is defined as the simultaneous presence of physical frailty and cognitive impairment among older adults without dementia. Previous studies have revealed that neuropathological changes may contribute to the degeneration of subcortical nuclei in the process of cognitive impairment. However, it is unclear in CF. The aim of this study is to investigate the changes in subcortical nuclei in older adults with CF and their relationship with cognitive decline and physical frailty. Methods: A total of 26 older adults with CF and 26 matched healthy subjects were enrolled. Cognitive function and physical frailty were assessed with the Montreal Cognitive Assessment (MoCA) scale (Fuzhou version) and the Chinese version of the Edmonton Frailty Scale (EFS). Volumetric and diffusion tensor imaging (DTI) parameters of subcortical nuclei were measured with structural and DTI brain magnetic resonance imaging (MRI) and compared between groups. Partial correlation analysis was conducted between subcortical nuclei volumes, MoCA scores, and physical frailty indexes. Results: Significant volume reductions were found in five subcortical nuclei, including the bilateral thalami, left caudate, right pallidum, and accumbens area, in older adults with CF (P < 0.05), and the bilateral thalami was most obvious. Decreased fractional anisotropy and relative anisotropy values were observed only in the left thalamus in the CF group (P < 0.05). No group differences were found in apparent diffusion coefficient (ADC) values. The MoCA scores were positively correlated with the volumes of the bilateral thalami, right pallidum, and accumbens area (P < 0.05). Negative correlations were found between the physical frailty index and the volumes of the bilateral thalami, caudate, pallidum, and right accumbens area (P < 0.05). Conclusion: Microstructural changes occur in the subcortical nuclei of older adults with CF, and these changes are correlated with cognitive decline and physical frailty. Therefore, microstructural atrophy of the subcortical nuclei may be involved in the pathological progression of CF.

Dataset Information

Subcortical volumetric abnormalities in bipolar disorder.

Publications

Subcortical volumetric abnormalities in bipolar disorder.

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