Inhibition of FOXC2 restores epithelial phenotype and drug sensitivity in prostate cancer cells with stem-cell properties.
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ABSTRACT:
SUBMITTER: Paranjape AN
PROVIDER: S-EPMC5116559 | biostudies-literature | 2016 Nov
REPOSITORIES: biostudies-literature
Publications
Inhibition of FOXC2 restores epithelial phenotype and drug sensitivity in prostate cancer cells with stem-cell properties.
Paranjape A N AN Soundararajan R R Werden S J SJ Joseph R R Taube J H JH Liu H H Rodriguez-Canales J J Sphyris N N Wistuba I I Miura N N Dhillon J J Mahajan N N Mahajan K K Chang J T JT Ittmann M M Maity S N SN Logothetis C C Tang D G DG Mani S A SA
Oncogene 20160125 46
Advanced prostate adenocarcinomas enriched in stem-cell features, as well as variant androgen receptor (AR)-negative neuroendocrine (NE)/small-cell prostate cancers are difficult to treat, and account for up to 30% of prostate cancer-related deaths every year. While existing therapies for prostate cancer such as androgen deprivation therapy (ADT), destroy the bulk of the AR-positive cells within the tumor, eradicating this population eventually leads to castration-resistance, owing to the contin ...[more]
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