Iron Homeostasis Regulates the Genotoxicity of Escherichia coli That Produces Colibactin.
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ABSTRACT:
SUBMITTER: Tronnet S
PROVIDER: S-EPMC5116714 | biostudies-literature | 2016 Dec
REPOSITORIES: biostudies-literature
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Iron Homeostasis Regulates the Genotoxicity of Escherichia coli That Produces Colibactin.
Tronnet Sophie S Garcie Christophe C Rehm Nadine N Dobrindt Ulrich U Oswald Eric E Martin Patricia P
Infection and immunity 20161118 12
The genotoxin colibactin is a secondary metabolite produced by a variety of pathogenic enterobacteria. Its biosynthesis requires the enzymatic activity of the phosphopantetheinyl transferase (PPTase) ClbA. We previously showed that ClbA can also contribute to the production of siderophores. Because the biosynthesis of siderophores is regulated by iron availability, we hypothesized that iron could also modulate the production of colibactin through the transcriptional regulation of clbA This study ...[more]
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