Ontology highlight
ABSTRACT:
SUBMITTER: Yokoyama Y
PROVIDER: S-EPMC5117661 | biostudies-literature | 2016 Nov
REPOSITORIES: biostudies-literature
Yokoyama Yuhki Y Zhu Hengrui H Lee Jeong Heon JH Kossenkov Andrew V AV Wu Sherry Y SY Wickramasinghe Jayamanna M JM Yin Xiangfan X Palozola Katherine C KC Gardini Alessandro A Showe Louise C LC Zaret Kenneth S KS Liu Qin Q Speicher David D Conejo-Garcia Jose R JR Bradner James E JE Zhang Zhiguo Z Sood Anil K AK Ordog Tamas T Bitler Benjamin G BG Zhang Rugang R
Cancer research 20161101 21
The emergence of tumor cells with certain stem-like characteristics, such as high aldehyde dehydrogenase (ALDH) activity due to ALDH1A1 expression, contributes to chemotherapy resistance and tumor relapse. However, clinically applicable inhibitors of ALDH activity have not been reported. There is evidence to suggest that epigenetic regulation of stem-related genes contributes to chemotherapy efficacy. Here, we show that bromodomain and extraterminal (BET) inhibitors suppress ALDH activity by abr ...[more]