Ancestry-based stratified analysis of Immunochip data identifies novel associations with celiac disease.

ABSTRACT: To identify candidate genes in celiac disease (CD), we reanalyzed the whole Immunochip CD cohort using a different approach that clusters individuals based on immunoancestry prior to disease association analysis, rather than by geographical origin. We detected 636 new associated SNPs (P<7.02 × 10^-07) and identified 5 novel genomic regions, extended 8 others previously identified and also detected 18 isolated signals defined by one or very few significant SNPs. To test whether we could identify putative candidate genes, we performed expression analyses of several genes from the top novel region (chr2:134533564-136169524), from a previously identified locus that is now extended, and a gene marked by an isolated SNP, in duodenum biopsies of active and treated CD patients, and non-c

SUBMITTER: Garcia-Etxebarria K 

PROVIDER: S-EPMC5117923 | biostudies-literature | 2016 Dec

REPOSITORIES: biostudies-literature