Ontology highlight
ABSTRACT:
SUBMITTER: Brent MR
PROVIDER: S-EPMC5117949 | biostudies-literature | 2016 Nov
REPOSITORIES: biostudies-literature
Trends in genetics : TIG 20161006 11
One of the principal mechanisms by which cells differentiate and respond to changes in external signals or conditions is by changing the activity levels of transcription factors (TFs). This changes the transcription rates of target genes via the cell's TF network, which ultimately contributes to reconfiguring cellular state. Since microarrays provided our first window into global cellular state, computational biologists have eagerly attacked the problem of mapping TF networks, a key part of the ...[more]