Ontology highlight
ABSTRACT:
SUBMITTER: Kang CS
PROVIDER: S-EPMC5118032 | biostudies-literature | 2016 Oct
REPOSITORIES: biostudies-literature
Kang Chi Soo CS Ren Siyuan S Sun Xiang X Chong Hyun-Soon HS
ChemMedChem 20160914 19
Iron chelation therapy has been recognized as a promising antitumor therapeutic strategy. Herein we report a novel theranostic agent for targeted iron chelation therapy and near-infrared (NIR) optical imaging of cancers. The theranostic agent was prepared by incorporation of a polyaminocarboxylate-based cytotoxic chelating agent (N-NE3TA; 7-[2-[(carboxymethyl)amino]ethyl]-1,4,7-triazacyclononane-1,4-diacetic acid) and a NIR fluorescent cyanine dye (Cy5.5) onto a tumor-targeting transferrin (Tf). ...[more]