Ontology highlight
ABSTRACT:
SUBMITTER: Wang Y
PROVIDER: S-EPMC5118670 | biostudies-literature | 2016
REPOSITORIES: biostudies-literature
Wang Yuqiong Y Jin Gang G Li Quanjiang Q Wang Zhiping Z Hu Weimin W Li Ping P Li Shude S Wu Hongyu H Kong Xiangyu X Gao Jun J Li Zhaoshen Z
Journal of Cancer 20161022 14
Hedgehog(HH) pathway is found to be activated through a manner of canonical, or the non-canonical HH pathways. Distinct hyperplasia stroma around tumor cells is supposed to express pro-inflammatory cytokines abundantly, such as tumor necrosis factor-α (TNF-α) and interleukin-1β (IL-1β), etc. in pancreatic ductal adenocarcinoma (PDAC) tissues. In this study we observed the effects of TNF-α and IL-1β on HH pathway activation in PDAC cells, and explored their activation manners. Our results showed ...[more]