Ontology highlight
ABSTRACT:
SUBMITTER: Mozziconacci O
PROVIDER: S-EPMC5118937 | biostudies-literature | 2016 Feb
REPOSITORIES: biostudies-literature
Mozziconacci Olivier O Okbazghi Solomon S More Apurva S AS Volkin David B DB Tolbert Thomas T Schöneich Christian C
Journal of pharmaceutical sciences 20160111 2
As part of a series of articles in this special issue evaluating model IgG1-Fc glycoforms for biosimilarity analysis, 3 well-defined IgG1-Fc glycoforms (high mannose-Fc, Man5-Fc, and N-acetylglucosamine-Fc) and a nonglycosylated Fc protein (N297Q-Fc) were examined in this work to elucidate chemical degradation pathways. The 4 proteins underwent a combination of accelerated thermal stability studies and 4 independent forced degradation studies (UV light, metal-catalyzed oxidation, peroxyl radical ...[more]