Ontology highlight
ABSTRACT:
SUBMITTER: Myers AP
PROVIDER: S-EPMC5119517 | biostudies-literature | 2016 Apr
REPOSITORIES: biostudies-literature
Myers Andrea P AP Filiaci Virginia L VL Zhang Yuping Y Pearl Michael M Behbakht Kian K Makker Vicky V Hanjani Parviz P Zweizig Susan S Burke James J JJ Downey Gordon G Leslie Kimberly K KK Van Hummelen Paul P Birrer Michael J MJ Fleming Gini F GF
Gynecologic oncology 20160401 1
<h4>Objective</h4>Rapamycin analogs have reproducible but modest efficacy in endometrial cancer (EC). Identification of molecular biomarkers that predict benefit could guide clinical development.<h4>Methods</h4>Fixed primary tissue and whole blood were collected prospectively from patients enrolled on GOG 248. DNA was isolated from macro-dissected tumors and blood; next-generation sequence analysis was performed on a panel of cancer related genes. Associations between clinical outcomes [response ...[more]