Ontology highlight
ABSTRACT:
SUBMITTER: Riou C
PROVIDER: S-EPMC5119638 | biostudies-literature | 2016 Dec
REPOSITORIES: biostudies-literature
Tuberculosis (Edinburgh, Scotland) 20160809
HIV-1 is recognized to increase the risk for tuberculosis even before CD4+ T cell deficiency is profound. To better understand how HIV-1 alters immunity to latent tuberculosis, we compared the magnitude and functional profile of mycobacteria-specific CD4+ T cells between HIV-uninfected and HIV-infected individuals, using flow cytometry. In HIV-1 infection, IFN-γ single positive mycobacteria-specific CD4+ T cells were decreased, while the frequency of polyfunctional cells (IFN-γ+IL-2+TNF-α+) rema ...[more]