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Selective reduction of IFN-? single positive mycobacteria-specific CD4+ T cells in HIV-1 infected individuals with latent tuberculosis infection.

ABSTRACT: HIV-1 is recognized to increase the risk for tuberculosis even before CD4+ T cell deficiency is profound. To better understand how HIV-1 alters immunity to latent tuberculosis, we compared the magnitude and functional profile of mycobacteria-specific CD4+ T cells between HIV-uninfected and HIV-infected individuals, using flow cytometry. In HIV-1 infection, IFN-? single positive mycobacteria-specific CD4+ T cells were decreased, while the frequency of polyfunctional cells (IFN-?+IL-2+TNF-?+) remained unchanged. Moreover, the proportion of IFN-? single positive cells correlated inversely with viral replication. Our results suggest that HIV-1 affects mycobacteria-specific cells differentially, depending on their functional capacity.

SUBMITTER: Riou C 

PROVIDER: S-EPMC5119638 | biostudies-literature | 2016 Dec

REPOSITORIES: biostudies-literature

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Selective reduction of IFN-γ single positive mycobacteria-specific CD4+ T cells in HIV-1 infected individuals with latent tuberculosis infection.

Riou Catherine C   Bunjun Rubina R   Müller Tracey L TL   Kiravu Agano A   Ginbot Zekarias Z   Oni Tolu T   Goliath Rene R   Wilkinson Robert J RJ   Burgers Wendy A WA  

Tuberculosis (Edinburgh, Scotland) 20160809

HIV-1 is recognized to increase the risk for tuberculosis even before CD4+ T cell deficiency is profound. To better understand how HIV-1 alters immunity to latent tuberculosis, we compared the magnitude and functional profile of mycobacteria-specific CD4+ T cells between HIV-uninfected and HIV-infected individuals, using flow cytometry. In HIV-1 infection, IFN-γ single positive mycobacteria-specific CD4+ T cells were decreased, while the frequency of polyfunctional cells (IFN-γ+IL-2+TNF-α+) rema  ...[more]