Ontology highlight
ABSTRACT:
SUBMITTER: Patil PC
PROVIDER: S-EPMC5119859 | biostudies-literature | 2016 Nov
REPOSITORIES: biostudies-literature
Bioorganic & medicinal chemistry 20160907 21
The development and use of small-molecule inhibitors of the adherence of Porphyromonas gingivalis to oral streptococci represents a potential therapy for the treatment of periodontal disease as these organisms work in tandem to colonize the oral cavity. Earlier work from these laboratories demonstrated that a small synthetic peptide was an effective inhibitor of the interaction between P. gingivalis and Streptococcus gordonii and that a small-molecule peptidomimetic would provide a more stable, ...[more]