Ontology highlight
ABSTRACT:
SUBMITTER: Fujikawa T
PROVIDER: S-EPMC5119890 | biostudies-literature | 2016 Nov
REPOSITORIES: biostudies-literature
Fujikawa Teppei T Castorena Carlos M CM Pearson Mackenzie M Kusminski Christine M CM Ahmed Newaz N Battiprolu Pavan K PK Kim Ki Woo KW Lee Syann S Hill Joseph A JA Scherer Philipp E PE Holland William L WL Elmquist Joel K JK
eLife 20161122
Exercise has numerous beneficial metabolic effects. The central nervous system (CNS) is critical for regulating energy balance and coordinating whole body metabolism. However, a role for the CNS in the regulation of metabolism in the context of the exercise remains less clear. Here, using genetically engineered mice we assessed the requirement of steroidogenic factor-1 (SF-1) expression in neurons of the ventromedial hypothalamic nucleus (VMH) in mediating the beneficial effects of exercise on m ...[more]