Ontology highlight
ABSTRACT:
SUBMITTER: Shao S
PROVIDER: S-EPMC5119991 | biostudies-literature | 2016 Nov
REPOSITORIES: biostudies-literature
Shao Sichen S Murray Jason J Brown Alan A Taunton Jack J Ramakrishnan V V Hegde Ramanujan S RS
Cell 20161101 5
In eukaryotes, accurate protein synthesis relies on a family of translational GTPases that pair with specific decoding factors to decipher the mRNA code on ribosomes. We present structures of the mammalian ribosome engaged with decoding factor⋅GTPase complexes representing intermediates of translation elongation (aminoacyl-tRNA⋅eEF1A), termination (eRF1⋅eRF3), and ribosome rescue (Pelota⋅Hbs1l). Comparative analyses reveal that each decoding factor exploits the plasticity of the ribosomal decodi ...[more]