Ontology highlight
ABSTRACT:
SUBMITTER: Persi E
PROVIDER: S-EPMC5120217 | biostudies-literature | 2016 Nov
REPOSITORIES: biostudies-literature
Persi Erez E Wolf Yuri I YI Koonin Eugene V EV
Nature communications 20161118
Protein repeats are considered hotspots of protein evolution, associated with acquisition of new functions and novel phenotypic traits, including disease. Paradoxically, however, repeats are often strongly conserved through long spans of evolution. To resolve this conundrum, it is necessary to directly compare paralogous (horizontal) evolution of repeats within proteins with their orthologous (vertical) evolution through speciation. Here we develop a rigorous methodology to identify highly perio ...[more]