Ontology highlight
ABSTRACT:
SUBMITTER: Perez-Guijarro E
PROVIDER: S-EPMC5120223 | biostudies-literature | 2016 Nov
REPOSITORIES: biostudies-literature
Pérez-Guijarro Eva E Karras Panagiotis P Cifdaloz Metehan M Martínez-Herranz Raúl R Cañón Estela E Graña Osvaldo O Horcajada-Reales Celia C Alonso-Curbelo Direna D Calvo Tonantzin G TG Gómez-López Gonzalo G Bellora Nicolas N Riveiro-Falkenbach Erica E Ortiz-Romero Pablo L PL Rodríguez-Peralto José L JL Maestre Lorena L Roncador Giovanna G de Agustín Asensio Juan C JC Goding Colin R CR Eyras Eduardo E Megías Diego D Méndez Raúl R Soengas María S MS
Nature communications 20161118
Nuclear 3'-end-polyadenylation is essential for the transport, stability and translation of virtually all eukaryotic mRNAs. Poly(A) tail extension can also occur in the cytoplasm, but the transcripts involved are incompletely understood, particularly in cancer. Here we identify a lineage-specific requirement of the cytoplasmic polyadenylation binding protein 4 (CPEB4) in malignant melanoma. CPEB4 is upregulated early in melanoma progression, as defined by computational and histological analyses. ...[more]